A data-driven framework reconstructs the molecular continuum of human MASLD progression
Transcriptomics-based disease trajectory analysis captures MASLD progression We first sought to determine whether MASLD progression could be represented as a continuous molecular process using liver transcriptomic data alone. Specifically, we asked whether patients could be ordered along a disease axis that recapitulates histological severity while providing finer resolution than discrete staging. Given variability between patients, … Read more